After menopause, which lipid parameter tends to decrease?

• A. LDL cholesterol
• B. Total cholesterol
• C. Triglycerides
• D. HDL cholesterol

Answer: (D)

Estrogen’s effects on lipid metabolism shape what happens to lipids after menopause. Estrogen tends to raise HDL levels by promoting production of HDL components (like apoA-I) and supporting enzymes that help form and maintain HDL, while also keeping HDL breakdown in check. When menopause brings a drop in estrogen, these protective influences wane. The result is a tendency for HDL cholesterol to fall, meaning the “good” cholesterol decreases. In contrast, LDL cholesterol and total cholesterol often rise after menopause, and triglycerides can increase as well, shifting the overall lipid profile toward a less favorable pattern.