Hormone therapy in women with POI is recommended for symptom relief and bone protection until approximately what age?

• A. The average age of natural menopause
• B. Age 50
• C. Age 60
• D. Indefinitely

Answer: (A)

In POI, estrogen deficiency causes symptoms and bone loss, so hormone therapy is used as a replacement to relieve symptoms and protect bone health. The goal is to continue this replacement until the age at which menopause would naturally occur in someone with normal ovarian function. That average menopause age is about 50 years, give or take a year or two. So the therapy is continued until roughly age 50, after which treatment is reassessed based on symptoms, risk factors, and patient preference. Options suggesting continuation to age 60 or indefinitely aren’t aligned with how therapy is typically managed, and stopping around the natural menopause age minimizes long-term exposure risks while matching the body's normal timeline.